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abstract::The three types of interferon (IFNs) are essential for immunity against at least some viruses in the mouse model of experimental infections, type I IFNs displaying the broadest and strongest anti-viral activity. Consistently, human genetic studies have shown that type II IFN is largely redundant for immunity against v...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.10.016
更新日期:2011-12-01 00:00:00
abstract::The rate of new virus discovery is increasing dramatically with improvements in sequencing and other molecular diagnostic platforms, and investments in sample collection and analysis. However, progress has been more limited in identification and implication of infectious agents that pose threats to human health and we...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.10.010
更新日期:2011-12-01 00:00:00
abstract::Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-...
journal_title:Current opinion in virology
pub_type: 杂志文章
doi:10.1016/j.coviro.2011.10.026
更新日期:2011-12-01 00:00:00
abstract::Positive strand RNA viruses cause membrane modifications which are microenvironments or larger intracellular compartments, also called 'viroplasms'. These compartments serve to concentrate virus and host factors needed to produce new genomes. Forming these replication sites often involves virus induced membrane synthe...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.09.009
更新日期:2011-11-01 00:00:00
abstract::We compare the design, mechanism of action, and clinical efficacy of two recently licensed paradigm shifting vaccines. Zostavax is the first vaccine licensed to prevent disease in patients already infected with a pathogen, and is contrasted with Gardasil and Cervarix, the first vaccines designed and licensed specifica...
journal_title:Current opinion in virology
pub_type: 杂志文章,评审
doi:10.1016/j.coviro.2011.07.007
更新日期:2011-10-01 00:00:00
abstract::Biological invasions occur when plants, animals, or microbes are introduced to a new geographic region, then spread and have negative consequences for the local ecosystem. Across both plant and animal hosts, viruses can play diverse roles in biological invasions. First, viruses can either decrease or increase the impa...
journal_title:Current opinion in virology
pub_type: 杂志文章
doi:10.1016/j.coviro.2011.05.018
更新日期:2011-07-01 00:00:00